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The Artinger Lab came back together for the annual SDB meeting. These are by far my favorite meetings, and this year was especially fun to see everyone together and catch up. What a great group! And many thanks to Kristin for creating such a wonderful academic family. Looking forward to emulating her amazing mentorship here at Lafayette!
Hot off the presses, our first publication of the lab is now out in Development... Mutations in cdon and boc affect trunk neural crest cell migration and slow-twitch muscle development in zebrafish The transmembrane proteins cdon and boc are implicated in regulating hedgehog signaling during vertebrate development. Recent work showing roles for these genes in axon guidance and neural crest cell migration suggest that cdon and boc may play additional functions in regulating directed cell movements. We use newly generated and existing mutants to investigate a role for cdon and boc in zebrafish neural crest cell migration. We find that single mutant embryos exhibit normal neural crest phenotypes, but that neural crest migration is strikingly disrupted in double cdon;boc mutant embryos. We further show that this migration phenotype is associated with defects in the differentiation of slow-twitch muscle cells, and the loss of a Col1a1a-containing extracellular matrix, suggesting that neural crest defects may be a secondary consequence to defects in mesoderm development. Combined, our data add to a growing literature showing that cdon and boc act synergistically to promote hedgehog signaling during vertebrate development, and suggest that the zebrafish can be used to study the function of hedgehog receptor paralogs. This is cool...Development plants a tree for every paper that is published. Find our tree in the Forest of Biologists or read the original editorial describing the Forest of Biologists.
Our first lab outing! Great hike with the summer research crew up Mount Minsi along the Appalachian Trail. A little bit of smoke to remind us of the West Coast, but still good views and some of the Rhododendrons were flowering.
Congratulations to Hannah and Ben for giving two great poster presentations at the annual research day! If you missed their posters then pop into RISC to learn about some cool projects on the POU transcription factor family and genetic markers to study paternity in House Sparrow. Great job guys!
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